'Top-up' loading dose of phenytoin for status epilepticus Continuous ECG, blood pressure and respiratory rate monitoring is required during infusion as there is a risk of hypotension and bradycardia.ΔΆ.Do not administer as a continuous infusion.To avoid local venous irritation, inject sterile sodium chloride 0.9% through the vein or catheter before and after each phenytoin infusion.Give through an in-line filter (0.22 - 0.5microns) via an infusion pump. Give phenytoin over 30-40 minutes (rate 1g in 250ml of sodium chloride 0.9%.Volume of IV Phenytoin (ml) (vial = 250mg/5ml) Table 1 - IV phenytoin loading dose Weight (kg) Ensure ECG, blood pressure and respiratory function are monitored throughout the duration of the infusion. Phenytoin sodium IV 18mg/kg (see Table 1 below). If the patient has not already received phenytoin then give: Initial loading dose of phenytoin for status epilepticus Guideline for Phenytoin Dose Calculations 1.
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